罗开珺 硕士生导师
云南大学东陆学者
Email：kaijun_luo@ynu.edu.cn
个人简介：
罗开珺，云南省病毒与免疫国际联合实验室主任，育部重点领域病毒学教学资源建设-昆虫病毒知识领域专家协助组成员，云南省引进高层次人才，无党派人士，云南大学东陆学者。首次提出细胞表面半通道hemichannel的开关调控细胞免疫反应，实现了一个理论上的突破。 在此理论指导下，围绕着茧蜂病毒对Innexin-hemichannel开关的调控展开研究，揭示了病毒通过关闭细胞的hemichannel，阻断细胞间通讯调控的免疫抑制机制。该项研究成果“双斑侧沟茧蜂病毒免疫抑制机制”荣获2020年云南省自然科学奖二等奖。以通讯作者在Frontiers in Immunolgy，iScience等国际刊物上发表SCI论文30余篇。国际著名刊物Front Immunol、JBC、JV、JGV、Biology，等期刊审稿人。
2024年《病毒学》课程认定为省级线下一流本科课程
2023年度获国家重点领域教学资源建设《病毒学》课程建设优秀团队和优秀专家表彰
2023年任云南省病毒与免疫国际联合实验室 主任
2022年教育部重点领域病毒学教学资源建设-昆虫病毒知识领域专家协助组成员
2022年被认定为无党派人士
2020年获云南省自然科学奖二等奖
2020年度获课堂教学优秀奖
2018年评为东陆学者
2018年任云南省高校细胞通讯调控国际合作重点实验室 主任
2017年晋升为三级教授
2016年荣获伍达观优秀教师奖先进奖
2010年云南省引进高层次人才
招生专业：
细胞生物学硕士
生物化学与分子生物学硕士
生物与医药——细胞生物学、生物化学与分子生物学
研究方向：
近年以病毒-细胞通讯-免疫机制为模式系统，重点开展以下研究：
1. 茧蜂病毒-Innexin-hemichannel-免疫抑制相互作用机制
2. 病毒Connexin-hemichannel-免疫反应相互作用机制
代表性研究成果：
*Corresponding authors
#These authors contributed equally to this work
1. Tang, Hong-Mei, Qiong-Li Zhang, Xin Qiao, Ming-Wu Dai, Yong-Sheng Yuan, Xue-Mei Tang, Wen-Ji Yang, Rui Jing, Xing-Cheng Li, Qi Zhang, Xiang Yan, Yin-Chen Ma, Yong-Biao Huang, Li-Xiang Zhou, Jin Long, Nan-Nan Peng, Chen-Hui Cai, Jiang-Hui Meng, and Kai-Jun Luo. (2025) Innexin DNA-binding domains regulate Microplitis bicoloratus bracoviral transcription in symbiotic wasps. iScience. https://doi.org/10.1016/j.isci.2025.113276 （点评：云南大学罗开珺团队揭示茧蜂含DNA绑定结构域的Innexin蛋白调控茧蜂病毒转录调控的新机制https://mp.weixin.qq.com/s/N6ct_zIZUATl9YFc1Qofhw）
2. Meng, Jiang-Hui#，Huang, Yong-Biao#，Long, Jin#，Cai, Qiu-Chen#，Qiao, Xin#，Zhang, Qiong-Li#，Zhang, Li-Dan，Yan, Xiang，Jing, Rui，Liu, Xing-Shan，Zhou, Sai-Jun，Yuan, Yong-Sheng，Ma, Yin-Chen，Zhou, Li-Xiang，Peng, Nan-Nan，Li, Xing-Cheng，Cai, Cheng-Hui，Tang, Hong-Mei，Martins, André F.，Jiang, Jean X.，Luo, Kai-Jun*. （2024）Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS. iScience, 10.1016/j.isci.2024.109469.https://www.sciencedirect.com/science/article/pii/S2589004224006904 (点评：云南大学罗开珺团队揭示茧蜂ecSOD降低寄主ROS的机制https://mp.weixin.qq.com/s/3JDnH5WQq8OvtB_4ZgCbrQ)
3. Xing-Cheng Li#, Yin-Chen Ma#, Jin Long#, Xiang Yan#, Nan-Nan Peng#, Cheng-Hui Cai#, Wen-Feng Zhong#, Yong-Biao Huang, Xin Qiao, Xiang-Li Zhou, Qiu-Chen Cai, Chang-Xu Cheng, Gui-Fang Zhou, Yun-Feng Han, Hong-Yu Liu, Qi Zhang, Hong-Mei Tang, Jiang-Hui Meng, Kai-Jun Luo*. (2023) Frontiers in Immunology. Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda. Frontiers in Immunology (2023) 14: doi:10.3389/fimmu.2023.1289477. https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289477 (点评：罗开珺团队揭示茧蜂一次精准寄生有效防治害虫的机制 https://mp.weixin.qq.com/s/Buh6dxaOh9fxnJ27ZYWYFA)
4. Ming-Wu Dai, Kai-Jun Luo*. （2022）Envelope-Fusion-Syncytium formation in Microplitis bicoloratus bracovirus maturation. Viruses, 2022,14,2183. https://doi.org/ 10.3390/v14102183. https://www.mdpi.com/1999-4915/14/10/2183 (点评：本科生大创自选项目揭示茧蜂病毒囊膜-融合-合胞体的成熟机制 https://mp.weixin.qq.com/s/xB3F-PF99BrxP33_Y91jLA)
5. Jiang-Hui Meng#, Chang-Xu Chen#, Mohammad R. Ahmadian, Hong Zan, Kai-Jun Luo*, Jean X. Jiang*. （2022）Cross-activation of hemichannels/gap junctions and immunoglobulin-like domains in innate–adaptive immune responses. Frontiers in Immunology. 2022;13. doi:10.3389/fimmu.2022.882706. https://www.frontiersin.org/articles/10.3389/fimmu.2022.882706 (点评: 罗开珺团队在细胞免疫领域取得新进展https://mp.weixin.qq.com/s/u0DdYTZPYtu3bER1xZAQbg)
6. Gui-Fang Zhou#, Chang-Xu Chen#, Qiu-Chen Cai#, Xiang Yan#, Nan-Nan Peng#, Xing-Cheng Li#, Ji-Hui Cui，Yun-Feng Han，Qi Zhang，Jiang-Hui Meng，Hong-Mei Tang，Chen-hui Cai，Jin Long，Kai-Jun Luo*. (2022) Bracovirus sneaks into apoptotic bodies transmitting immunosuppressive signaling driven by integration-mediated eIF5A hypusination. Frontiers in Immunology 13. doi: 10.3389/fimmu.2022.901593. https://www.frontiersin.org/article/10.3389/fimmu.2022.901593 (点评：罗开珺团队揭示茧蜂病毒传递免疫抑制信号的新机制https://mp.weixin.qq.com/s/s5zg4qMveQVhzDl8FK15MQ)
7. Chang-Xu Chen#, Hao-Juan He#，Qiu-Chen Cai#, Wei Zhang#, Tian-Chao Kou，Xue-Wen Zhang，Shan You, Ya-Bin Chen, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Bracovirus-mediated innexin-hemichannel closure in cell disassembly. iScience, doi: 10.1016/j.isci.2021.102281. https://www.ncbi.nlm.nih.gov/pubmed/33817584
8. Qiu-Chen Cai#, Chang-Xu Chen#, Hong-Yu Liu#, Wei Zhang#, Yun-Feng Han, Qi Zhang, Gui-Fang Zhou, Sha Xu, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo*. (2021) Interactions of Vank proteins from Microplitis bicoloratus bracovirus with host Dip3 suppress eIF4E expression. Dev Comp Immunol, 103994. doi:https://doi.org/10.1016/j.dci.2021.103994. https://www.ncbi.nlm.nih.gov/pubmed/33417999
1. Chang-Xu Chen, Kai-Jun Luo*, Jia-Peng Yang, Yun-Chao Huang*, Eduardo R. Cardenas, Bruce J. Nicholson, and Jean X. Jiang* (2021). Connexins and cAMP cross-talk in cancer progression and metastasis. Cancers (Basel) 13. DOI: 10.3390/cancers13010058. https://encyclopedia.pub/7122. https://www.ncbi.nlm.nih.gov/pubmed/33379194
2. Kai-Jun Luo*, Chang-Xu Chen, Jia-Peng Yang, Yun-Chao Huang *, Eduardo R. Cardenas, and Jean X. Jiang * (2020). Connexins in Lung Cancer and Brain Metastasis. Frontiers in Oncology 10. DOI:10.3389/fonc.2020.599383. https://www.frontiersin.org/article/10.3389/fonc.2020.599383
3. Ji-Hui Cui#, Shu-Mei Dong#, Chang-Xu Chen#, Wei Xiao#, Qiu-Cheng Cai, Li-Dan Zhang, Hao-Juan He, Wei Zhang, Xue-Wen Zhang, Tian Liu, Lei Ding, Yang Yang, Jian-Hua Lai, Qi-Shun Zhu, and Kai-Jun Luo*. (2019) Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura. Dev Comp Immunol 95, 101-107. https://www.ncbi.nlm.nih.gov/pubmed/30776419
9. Li-Dan Zhang #, Qiu-Cheng Cai #, Ji-Hui Cui #, Wei Zhang #, Shu-Mei Dong #, Wei Xiao #, Jiang Li, Tian-Chao Kou, Xue-Wen Zhang, Hao-Juan He, Lei Ding, Yang Yang, Jian-Hua Lai, Ming Li, Qi-Shun Zhu, Kai-Jun Luo*. (2019) A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus. Dev Comp Immunol 92, 129-139. https://www.ncbi.nlm.nih.gov/pubmed/30471301
10. Ji-Hui Cui #, Yan-Bin Chen #, Ming Li #, Qiu-Cheng Cai, Li-Dan Zhang, Zi-Yun Lu, Jian-Cheng Li, Qi-Shun Zhu, Gang Ji *, Kai-Jun Luo*. (2018) Cryo-EM structure reveals cylindrical nucleocapsids from two polydnaviruses. Arch Virol 163, 3357-3363. https://www.ncbi.nlm.nih.gov/pubmed/30173353
11. Wei Zhang #, Meng-Wei Liu #, Ming Li #, Wei Xiao #, Xue-Wen Zhang Hao-Juan He, Yan-Bin Chen, Lei Ding, Kai-Jun Luo*. (2018) Unexpected link between insect innexins and apoptosis of HeLa cells. Arch Insect Biochem Physiol 99, e21473. https://www.ncbi.nlm.nih.gov/pubmed/29862562
12. Shu-Mei Dong, Ji-Hui Cui, Wei Zhang, Xue-Wen Zhang, Tian-Chao Kou, Qiu-Chen Cai, Sha Xu, Dong-Shuai Yu, Lei Ding, Jian-Hua Lai, Ming Li, Kai-Jun Luo*. (2017). Inhibition of translation initiation factor eIF4A is required for apoptosis mediated by Microplitis bicoloratus bracovirus. Arch Insect Biochem Physiol 96, e21423. https://www.ncbi.nlm.nih.gov/pubmed/28940716
13. Tian-Chao Kou #, Yue-Tong Liu #, Ming Li #, Yang Yang #, Wei Zhang, Ji-Hui Cui, Xue-Wen Zhang, Shu-Mei Dong, Sha Xu, Shan You, Dong-Shuai Yu, Zun-Yu Pang, Kai-Jun Luo*. (2017). Identification of β-chain of FoF1-ATPase in apoptotic cell population induced by Microplitis bicoloratus bracovirua and its role in the development of Spodoptera litura. Arch Insect Biochem Physiol 95, e21389. https://www.ncbi.nlm.nih.gov/pubmed/28557004
14. Dong-Shuai Yu #, Ya-Bin Chen #, Ming Li #, Ming-Jun Yang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). A polydnaviral genome of Microplitis bicoloratus bracovirus and molecular interactions between the host and virus involved in NF-κB signaling. Arch Virol 161, 3095-3125. https://www.ncbi.nlm.nih.gov/pubmed/27522588
15. Ya-Bin Chen #, Wei Xiao #, Ming Li #, Yan Zhang, Yang Yang, Jian-Sheng Hu, Kai-Jun Luo*. (2016). N-terminally elongated SpliInx2 and SpliInx3 reduce baculovirus-triggered apoptosis via hemichannel closure. Arch Insect Biochem Physiol 92, 24-37. https://www.ncbi.nlm.nih.gov/pubmed/27030553
16. Lin-E Guo #, Jun-Feng Zhang #, Xin-Yi Liu, Li-Mei Zhang, Hong-Li Zhang, Jian-Hua Chen, Xiao-Guang Xie, Ying Zhou*, Kai-Jun Luo*, Ju-Yong Yoon*. (2015) Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell. Anal Chem 87, 1196-1201. https://www.ncbi.nlm.nih.gov/pubmed/25511872
17. Zunyu Pang #，Ming Li #，Dongshuai Yu #，Yan Zhang，Xinyi Liu，Xinglai Ji，Yang Yang，Jiansheng Hu，Kaijun Luo*. (2015). Two innexins of Spodoptera litura influences hemichannel and gap junction functions in cellular immune responses，Arch Insect Biochem Physiol 90, 43-57. https://www.ncbi.nlm.nih.gov/pubmed/25939810
18. Ming Li #，Zunyu Pang #，Wei Xiao #，Xinyi Liu，Yan Zhang，Minjun Yang，Yang Yang，Jiansheng Hu，Kaijun Luo*. (2014). A Transcriptome analysis Suggests apoptosis-related signaling pathways in hemocytes of Spodoptera litura after parasitization by Microplitis bicoloratus，PLoS ONE 9(10),1-18, e110967. https://www.ncbi.nlm.nih.gov/pubmed/25350281
19. Tian Liu #，Ming Li #，Yan Zhang，Zunyu Pang，Wei Xiao，Yang Yang，Kaijun Luo*. (2013). A role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis, PLoS ONE, 8(7), e70456. https://www.ncbi.nlm.nih.gov/pubmed/23936205
