刘静 副研究员，硕士生导师
“兴滇英才计划”青年人才
Email:liujingxiufu@ynu.edu.cn
个人简介：
刘静，博士，副研究员，现任生命科学学院生物化学与分子生物学专业硕士生导师。2017年博士毕业于南京大学模式动物研究所，2017-2019年在南京大学从事博士后研究工作。2020年7月到云南大学任助理研究员，2023年任副研究员，研究方向主要集中在以基因工程小鼠为研究模型，借助动物细胞实验，探究脂质代谢紊乱相关代谢性疾病如肥胖、糖尿病、心血管疾病及非酒精性脂肪性肝病等疾病的发病机制，并寻找潜在的防治靶点；此外，还探究动物组织和细胞中不同类型的脂滴在代谢性疾病中的作用。以一作或共同一作在EMBO Molecular Medicine（封面故事）、Plos Genetics、Science Advance、Science China Life Sciences等杂志上发表文章；以共通讯在Adipocyte上发表文章；参与发表Journal of Experimental Medicine、Journal of Clinical Investigation、Nature Communctions、Journal of Biological Chemistry、Proc Natl Acad Sci U S A.、Journal of Genetics and Genomics和Journal of Cell Biology等文章。获国家自然科学基金青年和地区基金支持；获云南省面上项目支持；获云南省肿瘤免疫防治研究重点实验室开放课题支持；获云南省“兴滇英才计划”—青年人才称号；获云南省自然科学奖二等奖（成员之一）。指导本科生获得生科竞赛省级三等奖1项。
招生专业：
生物化学与分子生物学
研究方向：
近年主要以基因工程小鼠为研究模型，并借助动物细胞实验，重点开展以下研究：
1、探究脂质代谢紊乱相关代谢性疾病如肥胖、糖尿病、心血管疾病及非酒精性脂肪性
肝病等疾病的发病机制，并寻找潜在的防治靶点；
2、探究动物组织和细胞中不同类型的脂滴在代谢性疾病中的作用；
代表性研究成果：
1. Jing Liu#, Xijun Liang#, Danxia Zhou, Ling Lai, Liwei Xiao, Lin Liu, Tingting Fu, Yan Kong, Qian Zhou, Rick B Vega, Min-Sheng Zhu, Daniel P Kelly, Xiang Gao, Zhenji Gan*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO molecular medicine, 2016, 8(10):1212-1228.
2. Xiao Liwei#, Liu Jing#, Sun Zongchao#, Yin Yujing, Mao Yan, Xu Dengqiu, Liu Lin, Xu Zhisheng, Guo Qiqi, Ding Chenyun, Sun Wanping, Yang Likun, Zhou Zheng, Zhou Danxia, Fu Tingting, Zhou Wenjing, Zhu Yuangang, Chen Xiao-Wei, Li John Zhong, Chen Shuai, Xie Xiaoduo, Gan Zhenji*. AMPK-dependent and-independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genetics, 2021, 17(3): 0-e1009488.
3. Liwei Xiao#, Yujing Yin#, Zongchao Sun#, Jing Liu#, Yuhuan Jia, Likun Yang, Yan Mao, Shujun Peng, Zhifu Xie, Lei Fang, Jingya Li, Xiaoduo Xie*, Zhenji Gan*. AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Science Advance. 2024 Feb 9;10(6):eadj2752.
4. Jing Liu; Xijun Liang; Zhenji Gan*; Transcriptional regulatory circuits controlling muscle fiber type switching. Science China Life Sciences, 2015, 58(4): 321-327.
5. Xiaoqiong Tan#, Tingting Zhu#, Linqiang Zhang, Lin Fu, Ying Hu, Huiqin Li, Chengbin Li, Jingjing Zhang, Bin Liang*, Jing Liu*. miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes. Adipocyte, 2022, 11(1): 120-132.
6. Yujing Yin#, Dengqiu Xu#, Yan Mao#, Liwei Xiao, Zongchao Sun, Jing Liu, Danxia Zhou, Zhisheng Xu, Lin Liu, Tingting Fu, Chenyun Ding, Qiqi Guo, Wanping Sun, Zheng Zhou, Likun Yang, Yuhuan Jia, Xinyi Chen, Zhenji Gan*. FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. Journal of experimental medicine, 2022, 219(5): e20212491.
7. Shengqi He, Tingting Fu, Yue Yu, Qinhao Liang, Luyao Li, Jing Liu, Xuan Zhang, Qian Zhou, Qiqi Guo, Dengqiu Xu, Yong Chen, Xiaolong Wang, Yulin Chen, Jianmiao Liu, Zhenji Gan*, Yong Liu*. IRE1alpha regulates skeletal muscle regeneration through Myostatin mRNA decay. Journal of Clinical Investigation, 2021, 17(131): 1-17.
8. Xijun Liang#, Lin Liu#, Tingting Fu, Qian Zhou, Danxia Zhou, Liwei Xiao, Jing Liu, Yan Kong, Hui Xie, Fanchao Yi, Ling Lai, Rick B. Vega, Daniel P. Kelly, Steven R. Smith, Zhenji Gan*. Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. Journal of biological chemistry, 2016, 291(49): 25306-25318.
9. Zongchao Sun#, Likun Yang#, Abdukahar Kiram#, Jing Yang#, Zhuangzhuang Yang, Liwei Xiao, Yujing Yin, Jing Liu, Yan Mao, Danxia Zhou, Hao Yu, Zheng Zhou, Dengqiu Xu, Yuhuan Jia, Chenyun Ding, Qiqi Guo, Hongwei Wang, Yan Li, Li Wang , Tingting Fu*, Shijun Hu*, Zhenji Gan*.FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment. Nature Communctions. 2023 Nov 6;14:7136.
10. Tingting Zhu#, Linqiang Zhang#, Chengbin Li, Xiaoqiong Tan, Jing Liu, Huiqin Li, Qijing Fan, Zhiguo Zhang, Mingfeng Zhan, Lin Fu, Jinbo Luo, Jiawei Geng*, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. The S100 calcium binding protein A11 promotes liver fibrogenesis by targeting TGF-β signaling. Journal of Genetics and Genomics, 2022, 49(4):338-349.
11. Lin Liu#, Jie Cai#, Huimin Wang#, Xijun Liang#, Qian Zhou#, Chenyun Ding, Yuangang Zhu, Tingting Fu, Qiqi Guo, Zhisheng Xu, Liwei Xiao, Jing Liu, Yujing Yin, Lei Fang, Bin Xue, Yan Wang, Zhuo-Xian Meng, Aibin He, Jian-Liang Li, Yong Liu, Xiao-Wei Chen*, Zhenji Gan*. Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis, Proc Natl Acad Sci U S A, 2018, 116(24): 11776-11785.
12. Lin Fu#, Jingjing Zhang#, Yanli Wang#, Huiyin Wu#, Xiumei Xu, Chunxia Li, Jirong Li, Jing Liu, Haizhen Wang, Xue Jiang, Zhihao Li, Yaomei He, Pingsheng Liu*, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. LET-767 determines lipid droplet protein targeting and lipid homeostasis. Journal of Cell Biology. 2024 Jun 3; 223(6):e202311024.
