张静静 硕士生导师
云南省“兴滇英才支持计划”-青年人才
云南大学“东陆青年学者”
Email：zhangjingjing@ynu.edu.cn
个人简介：
张静静，博士，副研究员，硕士生导师，云南省“兴滇英才支持计划”-青年人才，云南大学“东陆青年学者”，中国科学院-“西部青年学者”。从事脂滴生物学的研究，寻找脂滴发生、发展的调控因子，并研究其分子机理。在J Bio Chem、J Cell Biol、J Lipid Res (封面故事)、BBA-Mol Cell Biol L、Mol Biol Evol和G3-Genes Genom Genet等SCI期刊发表研究论文多篇。主持科技部重大科技专项（课题负责人）、国自然青年/地区基金、中国博士后基金面上项目、中科院“西部之光”人才项目、云南省兴滇青年人才专项和云南省科技厅重点/面上项目。研究成果获云南省自然科学二等奖（第二完成人，2024）。
招生专业：
生物化学与分子生物学硕士
生物与医药——生物化学与分子生物学方向
研究方向：
近年以秀丽线虫为模式系统，重点开展以下研究：
1、脂滴发生、发展的调控因子及作用机制
2、脂滴蛋白靶向脂滴的调控因子及作用机制
3、应激下脂滴增大的作用机制
代表性研究成果（#表示共同第一作者，*表示通讯或并列通讯作者）
1. Lin Fu#, Jingjing Zhang#, Yanli Wang#, Huiyin Wu#, Xiumei Xu, Chunxia Li, Jirong Li, Jing Liu, Haizhen Wang, Xue Jiang, Zhihao Li, Yaomei He, Pingsheng Liu*, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. LET-767 determines lipid droplet protein targeting and lipid homeostasis. Journal of Cell Biology. 2024; 223(6):e202311024.
2. Yanli Wang#, Chunxia Li#, Jingjing Zhang#, Xiumei Xu, Lin Fu, Jie Xu, Hong Zhu, Ying Hu, Chengbin Li, Mengjie Wang, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans. J Bio Chem, 2022, 298(8):102179.
3. Jingjing Zhang#, Ying Hu#, Yanli Wang#, Lin Fu, Xiumei Xu, Chunxia Li, Jie Xu, Chengbin Li, Linqiang Zhang, Rendan Yang, Xue Jiang, Yingjie Wu, Pingsheng Liu*, Xiaoju Zou*, Bin Liang*. mmBCFA C17iso ensures endoplasmic reticulum integrity for lipid droplet growth. Journal of Cell Biology. 2021, 220(11): e202102122. ( Recommended in Faculty Opinions)
4. Ying Hu#, Yanli Wang#, Xuanjun Wang, Xiaoyun Wu, Lin Fu, Xiayu Liu, Yu Wen, Jun Sheng*, and Jingjing Zhang*. The role of cation diffusion facilitator CDF-1 in lipid metabolism in Caenorhabditis elegans, G3-Genes Genom Genet. 2021, 11(7): jkab120.
5. Yong Shao#, Hangyu Tian#, Jingjing Zhang#, Hamed Kharrati-Koopaee#, Xing Guo, Xiaolin Zhuang, Mingli Li, Hojjat Asadollahpour Nanaie, Elahe Dehghani Tafti, Bahador Shojaei, Mohammad Reza Namavar, Narges Sotoudeh, Adeola Oluwakemi Ayoola, Jiali Li, Bin Liang*, Ali Esmailizadeh*, Shu Wang*, Dongdong Wu*. Genomic and phenotypic analyses reveal mechanisms underlying homing ability in pigeon. Molecular Biology and Evolution. 2020 Jan 1;37(1):134-148.
6. Baoshen He#, Jingjing Zhang#, Yanli Wang, Yamei Li, Xiaoju Zou*, Bin Liang*. Identification of cytochome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. BBA-Molecular and Cell Biology of Lipids, 2018, 1863: 235–246.
7. Jingjing Zhang, Junjun Hao, Yuru Zhang, Yanli Wang, Mingyi Li, Huilai Miao, Xiaoju Zou*, Bin Liang*. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Journal of Lipid Research, 2017, 58(9), 1845-1854. (当期封面)
8. Yuru Zhang#, Haizhen Wang#, Jingjing Zhang# ,Ying Hu#, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou*, Bin Liang*. Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. BBA-Molecular and Cell Biology of Lipids, 2016, 1861(4):310-319.
9. Rendan Yang#, Yamei Li#, Yanli Wang, Jingjing Zhang, Qijing Fan, Jianlin Tan, Weizhen Li*, Xiaoju Zou*, Bin Liang*. NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans. Cell Reports, 2022, 38(2):110206.
10. Xiaoqiong Tan#, Tingting Zhu#, Linqiang Zhang, Lin Fu, Ying Hu, Huiqin Li, Chengbin Li, Jingjing Zhang, Bin Liang*, Jing Liu*. miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes. Adipocyte. 2022 Dec;11(1):120-132.
11. Jieyu Wu#, Xue Jiang#, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Lingqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou*, Bin Liang*. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Nature Communications. 2018, 9(1):1195.
