张子杰 研究员，博士生导师
Email：zijiezhang@ynu.edu.cn
个人简介：
张子杰，博士，研究员，现任云南大学 Bio-X交叉技术创新中心 副主任，云南疫苗实验室 副主任。
于2020年取得芝加哥大学系统生物学博士学位，致力于使用系统生物学思想，基因组学、免疫学与疫苗临床研等学科交叉研究方法理解疾病治疗和疫苗免疫应答的个体差异，开展免疫应答的精准医学研究，构建我国系统疫苗学研究体系。同时利用多组学分析揭示的免疫调控机制，发展基于重组蛋白、mRNA递送等平台的免疫调节剂、开发大分子药物。目前已在Nature Genetics、National Science Review、eClinicalMedicine 等期刊发表论文30余篇；主持国家重点研发计划、云南省生物医药重大专项等项目。
招生专业：
遗传学硕士、博士
生物信息学硕士
生物与医药硕士、博士
研究方向：
近年以系统生物学为核心，重点开展以下研究：
1、疫苗免疫应答的遗传、基因、免疫调控机制
2、单细胞多组学整合及AI虚拟细胞模型
3、靶向免疫调控的生物大分子药物开发
代表性研究成果：
1. Xuejiao Wang#, Qiqi Li#, Dongchen Han#, Fang Xie, Jinyong Wang, Yiying Li, Cuiqin Cheng, Yingjie Chu, Xia Liu, Qiutong Dong, Yanli Yu, Zheng Luo, Jincheng Guo*, Zijie Zhang*, and Yao Wang*. A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization. Journal of Agricultural and Food Chemistry 2024 72 (37), 20432-20443 共同通讯作者
2. Xuanjing Yu# ; Wei Yang# ; Wei Li; Na Wan; Guanghong Yan; Zumi Zhou; Xiao Zhu; Wei Su; Yani Li,; Chenyu Xing; Sifan Duan; Houze Yu; Xinshuai Zhao; Chunmei Li; Taicheng Zhou*; Dingyun You*; Jia Wei*; Zijie Zhang*. Safety, immunogenicity and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containing bivalent mRNA vaccine. hLife, 2024, 2(3): 113-125 （Cover article）通讯作者
3. Yue-Miao Zhang, Xing-Zi Liu, Zhao Zhang, Tai-Cheng Zhou, Xin Zhang, Hong-Yu Yang, Meng Tan, Nan Hu, Su-Fang Shi, Fang Wang, Rong Xu, Li-Jun Liu, Su-Xia Wang, Gang Liu, Fu-De Zhou, Ming-Hui Zhao, Hong Zhang, Ji-Cheng Lv*, Ya-Ping Zhang*, Zi-Jie Zhang*, Li Yang*. Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination. National Science Review, 2023, 10(5):nwac034 (Impact Factor = 20.6) 共同通讯作者
4. Yuemiao Zhang#, Mengting Luo#, Qingqin Wu, Yunxia Wang, Xupu Ma, Guanghong Yan, Sihang Zhang, Yanli Chen, Na Wan, Liang Zhang, Dingyun You, Jia Wei*, and Zijie Zhang*, Tai-Cheng Zhou* on be half of the Precise-CoVaccine study group. Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose. Cell Discovery, 2023, 9:7 (Impact Factor = 38) 共同通讯作者
5. Taicheng Zhou#; Tianpei Shi#; Ao Li#; Lingzhi Zhu#; Xinshuai Zhao#; Naiyin Mao; Wanting Qin; Hanfang Bi; Mei Yang; Muxian Dai; Fengwei Liu; Rong Wang; Wei Su; Liang Zhang; Wenbo Xu; Jia Wei*; Zijie Zhang*; A third dose of inactivated SARS-CoV-2 vaccine induces robust antibody responses in people with inadequate response to two-dose vaccination. National Science Review, 2022, 9(7):nwac066 (Impact factor = 23) 通讯作者
6. Yue-Miao Zhang; Xing-Zi Liu; Miao-Miao Lin; Jin-Can Zan; Yi-Tong Hu; Xiang-Qiu Wang; WenQi Wu; Tai-Cheng Zhou; Ji-Cheng Lv*; Hong Zhang*; Li Yang*; Zi-Jie Zhang*; Immunosuppression impaired the immunogenicity of inactivated SARS-CoV-2 vaccine in non-dialysis kidney disease patients. Journal of Infection, 2022, 85(2):184-187 (Impact factor = 38) 通讯作者
7. Tianpei Shi; Muxian Dai; Fengwei Liu; Jun Hu; Muhua Feng; Gangxu Xu; Yajing Wang; Lihong Zhang; Liang Zhang; Zijie Zhang*; Taicheng Zhou*; Jia Wei*; Dynamics of immune responses to inactivated COVID-19 vaccination over 8 months in China. Journal of Infection, 2022 86(1):106-108 (Impact factor = 38) 共同通讯作者
8. Yuemiao Zhang#, Xupu Ma#, Guanghong Yan#, Ying Wu#, Yanli Chen, Zumi Zhou, Na Wan, Wei Su, Feng-Wei Liu, Mu-Xian Dai, Mei Yang, Chunmei Li, Xuanjing Yu, Liang Zhang, Zhongfang Wang*, Tai-Cheng Zhou*, Dingyun You*, Jia Wei*, Zijie Zhang*. Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: a randomised, double-blinded, placebo-controlled, phase 2 trial. eClinicalMedicine, 2022 54:101680. (Impact Factor = 17) 通讯作者
9. Zijie Zhang#, Kaixuan Luo#, Zhongyu Zou, Maguanyun Qiu, Jiakun Tian, Laura Sieh, Hailing Shi, Yuxin Zou, Gao Wang, Jean Morrison, Allen C. Zhu, Min Qiao, Zhongshan Li, Matthew Stephens*, Xin He*, Chuan He*. Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability. Nature Genetics, 2020 52:939-949. （Impact Factor = 38）第一作者
10. Zijie Zhang, Qi Zhan, Mark Eckert, Allen Zhu, Agnieszka Chryplewicz, Dario F. De Jesus, Decheng Ren, Rohit N. Kulkarni, Ernst Lengyel, Chuan He* & Mengjie Chen*. RADAR: differential analysis of MeRIP-seq data with a random effect model. Genome Biology, 2019 20(1):294. （Impact Factor = 11）第一作者
