成睿 助理研究员，硕士生导师
云南大学“青年培优计划”引进人才
Email：ruicheng@ynu.edu.cn
个人简介：
成睿，2023年获得哈尔滨工业大学博士学位。同年，加入云南大学担任助理研究员及硕士生导师，专注于生物信息学领域的研究。目前，以第一作者（含共同）在Oncogene、Science China Life Sciences、Briefings in Bioinformatics等期刊发表SCI论文9篇；作为共同作者，在Cell Discovery、Nucleic Acids Research等期刊上发表SCI论文12篇。主持云南大学-生物医学应用转化研究发展基金项目1项、云南疫苗实验室项目1项、云南大学新引进人才科研启动项目1项。
招生专业：
生物信息学硕士
生物与医药专硕
研究方向：
生物信息学与免疫信息学
代表性研究成果：
1) Rui Cheng#, Lixing Xiao#, Wenyang Zhou#, Xiyun Jin, Zhaochun Xu, Chang Xu, Pingping Wang, Meng Luo, Mengyun Wang, Kexin Ma, Huimin Cao, Yan Huang, Xiaoyu Lin, Fenglan Pang, Yiqun Li, Qinghua Jiang*. A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients. Oncogene. 2021 Sep;40(35):5441-5450.
2) Rui Cheng#, Xiaoman Zheng#, Yingmei Wang#, Xing Ma#, Xin Liu#, Wenjun Xu, Mengyun Wang, Yuanpeng Gao, Xupeng Xing, Chuan Zhou, Hongzheng Sun, Zekun Guo, Fusheng Quan, Jun Liu*, Song Hua*, Yongsheng Wang*, Yong Zhang* & Xu Liu*. Modification of alternative splicing in bovine somatic cell nuclear transfer embryos using engineered CRISPR-Cas13d. SCIENCE CHINA Life Sciences. 2022 May 5.
3) Rui Cheng#, Zhaochun Xu#, Huimin Cao, Xiyun Jin, Wenyang Zhou, Meng Luo, Lixing Xiao, Qinghua Jiang*. Identification of alternative splicing-derived tumor-specific antigens for mRNA vaccine development. Briefings in Bioinformatics. 2022 Mar 10;23(2):bbab553.
4) Rui Cheng#, Xiaoman Zheng#, Yingmei Wang#, Mengyun Wang, Chuan Zhou, Jun Liu, Yong Zhang, Fusheng Quan* and Xu Liu*. Genome-wide analysis of alternative splicing differences between oocyte and zygote. Biology of Reproduction. 2020 Apr 24;102(5):999-1010.
5) Mengyun Wang#, Rui Cheng#, Hongjuan He, Zhengbin Han, Qiong Wu*. N4-acetylcytidine of Nop2 mRNA is Required to the Transition of Morula-to-Blastocyst. Cellular and Molecular Life Science. 2023 Sep 28;80(10):307.
6) Lixing Xiao#, Haoxiu Sun#, Rui Cheng#, Rongrong Yang, Xiyun Jin, Zhaochun Xu, Yideng Cai, Yuexin Yang, Fenglan Pang, Guangfu Xue, Pingping Wang*, Qinghua Jiang*, Huan Nie*. Functional Requirement of Alternative Splicing in Epithelial-Mesenchymal Transition of Pancreatic Circulating Tumor. Molecular Therapy: Nucleic Acid. 2024 Jan 24;35(1):102129.
7) Haoran Yu#, Yue Zhao#, Rui Cheng#, Mengyun Wang, Xin Hu, Ximeijia Zhang, Xiangqi Teng, Hongjuan He, Zhengbin Han, Xiao Han, Ziwen Wang, Bingjing Liu, Yan Zhang*, Qiong Wu*. Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver. Cellular and Molecular Life Science. 2024 Oct 9;81(1):429.
8) Lixing Xiao #, Guoying Zou #, Rui Cheng #, Pingping Wang, Kexin Ma, Huimin Cao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Yan Huang, Xiaoyu Lin, Huan Nie*, Qinghua Jiang*. Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma. BMC Cancer. 2021 Jun 15;21(1):703.
9) Yingmei Wang#, Xiaoman Zheng#, Rui Cheng#, Jing Han#, Xing Ma, Wenjun Xu, Lu Gao, Anmin Lei, Jun Liu, Fusheng Quan, Yong Zhang*, Xu Liu*. Asymmetric expression of maternal mRNA governs first cell-fate decision. Faseb Journal. 2021 Nov;35(11):e22006.
