孙建伟 教授，博士生导师
Email：jwsun@ynu.edu.cn
个人简介：
孙建伟，博士、教授、博士生导师。2019年入选云南省“兴滇人才”，2021年获“云南省杰出青年”基金项目资助，中国生物物理学会线粒体分会常务理事、中国细胞生物学会青年委员会委员，Genome Instability & Disease编委，Biophysics Reports、中国细胞生物学学报青年编委，国家自然科学基金委同行评议专家，云南省自然科学基金评审专家库专家。以通讯/共同通讯身份在Science China Life Sciences、Trends in Pharmacological Sciences、FEBS Journal、 Cell Communication & Signaling、Journal of Biological Chemistry等国际一流学术期刊发表近40篇。主持国家自然基金面上项目、云南高层次人才青年项目、云南省“杰出青年”项目、云南省重点项目等。
招生专业：
细胞生物学博士、硕士
生物化学与分子生物学博士、硕士
生物与医药——01细胞生物学、生物化学与分子生物学方向
研究方向：
近年以肿瘤细胞和小鼠为模式系统，重点开展以下研究：
1． 线粒体功能调控失调在肿瘤发生中作用及机制
2． 钙池操纵的钙内流（SOCE）介导线粒体功能调控癌症发生恶化及肿瘤抗药性的分子机制
3． 肿瘤发生与转移机制研究
代表性研究成果(*通讯作者)：
1. Weiyu Bai#, Rui Dong#, Chenglu Lu#, Lei Sang, Qinggang Hao, Yingru Zhang, Rongyuan Sun, Hayam Hamdy, Junling Shen, Wenjing Zhu*, Yan Sun*, Jianwei Sun*. The Wnt/β-catenin-P2-HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy. Revised in Journal of Translational Medicine. 2025
2. Xiangxiang Liu#, Yuanzhao Hu#, Liangwei Wu, Yiwen Zhang, Lei Sang, Yake Gao, Lei He, Wenyong Xiong*, Shengyu Yang*, Jianwei Sun*.FSCN1 promotes neonatal survival in mice by regulating glycerol-mediated gluconeogenesis. Acta Biochimica et Biophysica Sinica. 2025
3. Qiang Zhu, Xiaoming Chen, Xiaotao Duan*, Jianwei Sun*, Wen Yi*. Targeting glycosylation to enhance tumor immunotherapy. Trends in Pharmacological Sciences. 2025 Aug 14:S0165-6147(25)00156-7. doi: 10.1016/j.tips.2025.07.013.
4. Jianxin Zhao#, Zheng Zhao#, Wen Zhou, Jianzhi Zhang, Jinfeng Chen, Jianwei Sun* & Jing Li*. YEATS2 O-GlcNAcylation Promotes Chromatin Association of the ATAC Complex and Lung Cancer Tumorigenesis. Journal of Biological Chemistry. 2025 Jun 18:110388. doi: 10.1016/j.jbc.2025.110388.
5. Kaiyao Zhou#, Gangyun Wu#, Rui Dong, Changhao Kan, Lin Xie, Lijuan Gao, Hua Li*, Jianwei Sun* and Wenxiu Ning*. Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying. Cell regeneration. 2025,14:25 https://doi.org/10.1186/s13619-025-00242-0
6. Qinggang Hao#, Yan Bai#, Ruiqi Guan, Rui Dong, Weiyu Bai, Hayam Hamdy , Liqiong Wang, Mingyao Meng, Yan Sun*, Junling Shen* , Jianwei Sun*. VPS35/retromer dependent MT1-MMP regulation confer melanoma metastasis. Science China Life Sciences. 2025,68(7)：1996-2009. doi: 10.1007/s11427-024-2884-2.
7. Shao-han Xie#, Qian-qian Zhang#, Ying-shuang Miao, Jun-yi Hu, Rui-xuan Liu, Marco Pistolozzi, Yue-xiao Hu, Zhong-xue Guo, Zhi-wei Wu, Ruiqi Guan, Qing Zheng, Li-peng Xu, Tong-zheng Liu*, Xiao-yun Lu*, Jian-wei Sun*, and Feng Wang*. Generation of the ANLN exon 9 inclusion isoform is regulated by SRSF2 binding to ANLN pre-mRNA to promote breast cancer metastasis. Communication Biology. 2025
8. Sheng Yan#, Kemeng Yuan#, Xinyi Yao#, Qiang Chen, Jing Li* and Jianwei Sun*. 14-3-3ε augments OGT stability by binding with S20-phosphorylated OGT. Journal of Biological Chemistry. 2024 Sep 12:107774. doi: 10.1016/j.jbc.2024.107774
9. Weiyu Bai#, Chenghao Yan#, Yichen Yang#, Lei Sang, Qinggang Hao, Xinyi Yao,Yingru Zhang, Jia Yu, Yifan Wang, Xiaowen Li, Mingyao Meng, Jilong Yang, Junling Shen*, Yan Sun*, Jianwei Sun*. EGF/EGFR-YAP1/TEAD2 signaling upregulates STIM1 in vemurafenib resistant melanoma cells. FEBS Journal. 2024 Nov;291(22):4969-4983. doi: 10.1111/febs.17272.
10. Li Meng#, Rui Dong#, Weixiao Mi, Ke Qin, Xing Chen, Kunfu Ouyang, Jianwei Sun* and Jing Li*. The ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT. Journal of Biological Chemistry. 2024 Jun 4:107448. doi: 10.1016/j.jbc.2024.107448
11. Qinggang Hao#, Rui Dong#, Weiyu Bai#, Dong Chang#, Xinyi Yao, Yingru Zhang, Huangying Xu, Huiyan Li, Xiang Kui, Feng Wang*, Yan Wang*, Chengqin Wang*, Yujie Lei*, Yan Chen*, Junling Shen*, Lei Sang*, Yan Bai*, Jianwei Sun*. Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection. Biophysics Reports. 2024 Feb 29;10(1):15-21.doi: 10.52601/bpr.2023.230043.
12. Yake Gao#, Rui Dong#, Jiacong Yan#, Huicheng Chen#, Lei Sang, Xinyi Yao, Die Fan, Xin Wang, Xiaoyuan Zuo, Xu Zhang, Shengyu Yang*, Ze Wu*, Jianwei Sun*. Mitochondrial deoxyguanosine kinase is required for female fertility in mice. Acta Biochimica et Biophysica Sinica 2024:56(3): 427-439. doi: 10.3724/abbs.2024003.
13. Jie Li#, Xiangxiang Liu#, Bin Peng#, Tingting Feng#, Wen Zhou, Li Meng, Shanshan Zhao, Chen Wu, Shian Wu, Xing Chen, Xingzhi Xu*, Jianwei Sun* and Jing Li*. O-GlcNAc crosstalks with ADP-ribosylation via PARG. Journal of Biological Chemistry 2023 Oct 17:105354. doi: 10.1016/j.jbc.2023.105354
14. Weiyu Bai#, Qinggang Hao#, Zhimeng Zhang#, Bingxing Han, Huilin Xiao, Dong Chang, Yun Zhu*, Junling Shen*, Jianwei Sun*. Identification of a novel inflammation-related gene signature for predicting inflammatory breast cancer survival. Genome instability & disease 2023, 4, 154–175 (2023). doi: https://doi.org/10.1007/s42764-023-00102-8
15. Jie Li #, Muhammad Ahmad#, Lei Sang#, Yahui Zhan#, Yibo Wang, Yonghong Yan, Yue Liu, Weixiao Mi, Mei Lu, Yu Dai, Rou Zhang, Meng-Qiu Dong, Yun-Gui Yang, Xiaohui Wang*, Jianwei Sun*, Jing Li*. O-GlcNAcylation promotes the cytosolic localization of the m6A reader YTHDF1 and colorectal cancer tumorigenesis. Journal of Biological Chemistry. 2023 Apr 20;104738. doi: 10.1016/j.jbc.2023.104738.
16. Lei Sang#, Rui Dong#, Rui Liu#, Qinggang Hao#, Weiyu Bai, Jianwei Sun*. Caenorhabditis elegans NHR-14/HNF4α regulates DNA damage-induced apoptosis through cooperating with cep-1/ p53. Cell Communication & Signaling. 2022 Sep 1;20(1):135. doi: 10.1186/s12964-022-00920-5.
17. Junling Shen#, Jilong Yang#, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun*, Jianwei Sun*. PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas. Cancer Biology and Medicine. 2021 Sep 28;19(8):1211-1223. doi: 10.20892/j.issn.2095-3941.2020.0294
