任晓霞 副研究员
Email：renxiaoxia001@ynu.edu.cn
个人简介：
任晓霞，博士，副研究员，实验动物中心肿瘤模型平台负责人。2007年获得山西大学生命科学专业理学学士学位，2013年获得北京协和医学院生物化学与分子生物学专业理学博士学位，同年10月进入北京协和医学院基本外科实验室进行博士后工作，主要从事胰腺癌发生发展和化疗耐药方面的相关研究。博士后出站后进入中美冠科（北京）生物技术有限公司，任中国区终了药理学组Study Director（Scientist II），负责在各类小鼠肿瘤模型中肿瘤药物的药效筛选和评估工作。2020年进入云南大学实验动物中心工作，目前担任云南大学实验生物医药动物模型工程研究中心肿瘤模型平台负责人，昆明市实验动物协会客座专家，主持参与多项国家自然资金面上项目、青年项目、云南省科技厅基础研究计划项目等，发表SCI论文20余篇，其中以第一作者或通讯作者身份发表15篇。
招生专业：
生物化学与分子生物学
生物与医药——生物化学和动物学方向
研究方向：
近年以小鼠为模式动物，重点开展以下研究：
1、肿瘤化疗药物开发与药效评估
2、肿瘤动物模型开发
代表性研究成果：
1. XiaoXia Ren, XueLian Li, RunYu Zhao, Yun Li, Ran Song, MengChi Han, YuFei Yan, LiZhen Zeng, ZhongYan Cai, Feng Gao*;Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer. Inorg Chem. 2025，64(19):9596-9607.
2. Yun Li, Xiao-Qi Zheng, Ding Wang, Chun-Lai Wei, Ya-Man Huang, Meng-Chi Han, Ze-Ming Wang, Xue-Lian Li, Qing-Fang Li, Zhongyan Cai, Xiaoxia Ren*, Feng Gao*; Cyclometalated Iridium(III) Complexes with Optimally Allocated Excited-State Energy for Near-Infrared Photodynamic and Photothermal Therapy. Inorg Chem. 2025, doi: 10.1021/acs.inorgchem.5c03265.
3. Ran Song, Run-Yu Zhao, Ru Yan, Xue-Lian Li, Li-Zhen Zeng, Zhongyan Cai, Jingbo Chen*, Xiaoxia Ren*, Xiaohong Cheng*, Feng Gao*, Nonemissive Ruthenium Complexes for Near Infrared-II Photodynamic, Photothermal, Sonodynamic, and Sonothermal Therapy Against Drug-Resistant Cancer, Journal of Medicinal Chemistry, 2025, 68, 17653-17666.
4. Li-Zhen Zeng, Xue-Lian Li, Yu-Ang Deng, Run-Yu Zhao, Ran Song, Yu-Fei Yan, Meng-Fan Wang, Xiang-Han Wang, Xiaoxia Ren*, Feng Gao*, Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemo-Resistant Cancer, Inorganic Chemistry, 2025, 64, 967-977.
5. JiChao Guo, QiHong Feng, Shu Yang, Jiajia Du, Xuan Zhou, Si-Han Zhou, Longlong Zhang, Xiaoxia Ren*, Ming-Jin Xie*；Multifunctional Drug Delivery Nanoparticles Based on Fe-Containing Metal-Organic Framework for Fluorescence Image-Guided Combined Chemical/Chemodynamic/Photodynamic Colorectal Cancer Treatment, ACS Appl Bio Mater, 2025, doi: 10.1021/acsabm.5c01102.
6. Xue-Lian li; Meng-Fan wang; Li-Zhen Zeng; Guo-Kui Li; Run-Yu Zhao; Fu-Dan Liu; Yun Li;Yu-Fei Yan; Qishuai Liu; Zhao Li; Hongbin Zhang; Xiaoxia Ren*; Feng Gao* ; Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy, Angewandte Chemie International Edition, 2024, 63(27)
7. Yu‐Fei Yan; Xue‐Lian Li; Li‐Zhen Zeng; Qishuai Liu; Zhongyan Cai; Yanrong Ren; Xiaoxia Ren*; Feng Gao*; Antitumor Cream: Transdermal Hydrogel Containing Liposome‐Encapsulated Ruthenium Complex for Infrared‐Controlled Multimodal Synergistic Therapy, Advanced Healthcare Materials,2025, 14(3): e2403563
8. Ji-Chao Guo; Shi-Hui Deng; Shu-Min Zhou; Xuan Zhou; Jiajia Du; Si-Han Zhou; Qi-Hua Zhao;Zhong-Yan Cai; Xiaoxia Ren*; Ming-jin Xie* ; Responsive ZIF-90 nanocomposite material: targeteddelivery of 10-hydroxycamptothecine to enhance the therapeutic effect of colon cancer (HCT116)cells, RSC Med Chem, 2024, 15(8): 2663-2676
9. Zong-Ling Niu; Si-Han Zhou; Yuan-Yuan Wu; Tian-Tian Wu; Qi-Shuai Liu; Qi-Hua Zhao; HuaJi; Xiaoxia Ren*; Ming-Jin Xie* ; Multifunctional O-phenanthroline silver(I) complexes forantitumor activity against colorectal adenocarcinoma cells and antimicrobial properties bymultiple mechanisms, Journal of Inorganic Biochemistry, 2023, 246: 112293
10. Si-Han Zhou; Rui-Dong Wang; Tian-Tian Wu; Shi-Hui Deng; Ji-Chao Guo; Shu-Min Zhou; XuanZhou; Jiajia Du; Qi-Hua Zhao; Xiaoxia Ren*; Ming-jin Xie* ; Long rod-shaped gallium composite material: Self-separating material aggregation induced enhancement of ROS for photothermal/photodynamic therapy of HCT116 cells, European Journal of Medicinal Chemistry, 2023,262: 115892
11. Xiaoxia Ren; Genome-wide analysis reveals the emerging roles of long non-coding RNAs in cancer, ONCOLOGY LETTERS, 2020, 19(1): 588-594
12. Xiaoxia Ren; Yongxing Du; Lei You; Yupei Zhao ; Potential functions and implications of
circular RNA in gastrointestinal cancer, ONCOLOGY LETTERS, 2017, 14(6): 7016-7020
13. Xiaoxia Ren; Wenjing Zhao; Yongxing Du; Taiping Zhang; Lei You; Yupei Zhao ; Activator protein 1 promotes gemcitabine-induced apoptosis in pancreatic cancer by upregulating its downstream target Bim, ONCOLOGY LETTERS, 2016, 12(4): 4732-4738
14. Xiaoxia Ren; Wei Song; Wenjie Liu; Xin Guan; Fei Miao; Shiying Miao; Linfang Wang ; Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3, FEBS Letters, 2013, 587(12): 1793-1798
15. Xiaoxia Ren; Xin Zhang; Yuying Li; Zhuanhua Wang ; Epitope mapping and immunological characterization of a major allergen TBa in tartary buckwheat, Biotechnol Lett, 2010, 32(9): 1317-132
