王彦利，副研究员
Email：wangyanli@ynu.edu.cn
个人简介：
王彦利，博士，副研究员。2022年入选“云南省兴滇英才计划-青年人才”。从事“脂滴生物学-脂滴增大的机制”研究。目前以第一作者在J. Biol. Chem. (nature index)、J. Cell Biol. (nature index)、Molecules、G3-Genes Genom. Genet.、J. Agr. Food Chem.等国际专业SCI期刊发表研究论文6篇，参与在J. Am. Chem. Soc. (nature index)、Cell Rep.、Nat. Commun.、BBA-Mol. Cell Biol. L.、J. Lipid Res.、J. Biol. Chem.、Aging Cell等SCI期刊发表研究论文20余篇。参与申请发明专利4项，参与出版专著1部。已获得国家自然科学基金青年基金1项、国家自然科学基金地区基金1项，及云南省应用基础研究计划面上项目2项。
招生专业：
生物化学与分子生物学硕士
生物与医药——生物化学与分子生物学硕士
研究方向：
近年以秀丽线虫和细胞为模型，研究脂滴增大的分子机制，为研究脂质过度积累。
脂滴在细胞内动态调节细胞的脂质代谢和能量平衡，并且在生物体的生长、发育、生殖、衰老、抗逆境等方面发挥重要作用。脂滴存在于所有真核生物和部分原核生物中，其在脂肪组织的过度积累和非脂肪组织（如肝脏）中的异位存储会导致肥胖、脂肪肝、糖尿病等代谢性疾病。我们利用秀丽线虫/细胞为模型，研究脂滴增大（长大或融合）的分子机理，寻找调控脂质积累的新机理（新的脂滴蛋白，脂代谢酶，代谢通路），为揭示脂代谢紊乱相关疾病如脂肪肝的发病机理，寻找新的疾病标志物和治疗靶标。
代表性研究成果：
1. Lin Fu#, Jingjing Zhang#, Yanli Wang#, Huiyin Wu#, Chunxia Li, Jing Liu, Haizhen Wang, Jirong Li, Xue Jiang, Pingsheng Liu*, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. LET-767 determines lipid droplet protein targeting and lipid homeostasis. Journal of Cell Biology. 2024; 223(6):e202311024. (IF=7.2, Q1)
2. Yanli Wang#, Chunxia Li#, Jingjing Zhang#, Xiumei Xu, Lin Fu, Jie Xu, Hong Zhu, Ying Hu, Chengbin Li, Mengjie Wang, Yingjie Wu*, Xiaoju Zou*, Bin Liang*. Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans. J Bio Chem, 2022, 298(8):102179. (IF=4.3, Q2)
3. Jingjing Zhang#, Ying Hu#, Yanli Wang#, Lin Fu, Xiumei Xu, Chunxia Li, Jie Xu, Chengbin Li, Linqiang Zhang, Rendan Yang, Xue Jiang, Yingjie Wu, Pingsheng Liu*, Xiaoju Zou*, Bin Liang*. mmBCFA C17iso ensures endoplasmic reticulum integrity for lipid droplet growth. Journal of Cell Biology. 2021, 220(11): e202102122. (IF=7.2, Recommended in Faculty Opinions, Q1)
4. Ying Hu#, Yanli Wang#, Xuanjun Wang, Xiaoyun Wu, Lin Fu, Xiayu Liu, Yu Wen, Jun Sheng*, and Jingjing Zhang*. The role of cation diffusion facilitator CDF-1 in lipid metabolism in Caenorhabditis elegans, G3-Genes Genom Genet. 2021, 11(7): jkab120. (IF=2.5, Q3)
5. Baoshen He#, Jingjing Zhang#, Yanli Wang, Yamei Li, Xiaoju Zou*, Bin Liang*. Identification of cytochome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. BBA-Molecular and Cell Biology of Lipids, 2018, 1863: 235–246. (IF=4.1, Q2)
6. Jingjing Zhang, Junjun Hao, Yuru Zhang, Yanli Wang, Mingyi Li, Huilai Miao, Xiaoju Zou*, Bin Liang*. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Journal of Lipid Research, 2017, 58(9), 1845-1854. (当期封面文章, IF=5.7, Q2)
7. Rendan Yang#, Yamei Li#, Yanli Wang, Jingjing Zhang, Qijing Fan, Jianlin Tan, Weizhen Li*, Xiaoju Zou*, Bin Liang*. NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans. Cell Reports, 2022, 38(2):110206. (IF=8.1, Q1)
8. Jieyu Wu#, Xue Jiang#, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Lingqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou*, Bin Liang*. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Nature Communications. 2018, 9(1):1195. (IF=17.2, Q1)
9. Chaojun Lu, Yang Meng, Yanli Wang, Tao Zhang, Guifang Yang, Minghe Mo, Kaifang Ji, Lianming Liang, Chenggang Zou*; Keqin Zhang*. Survival and infectivity of second-stage root-knot nematode Meloidogyne incognita juveniles depend on lysosome-mediated lipolysis. J Bio Chem. 2022, 298(3):101637. (IF=5.041)
10. Gonghua Li, Feifei Han, Fuhui Xiao, Kangsuyun Gu, Qiu Shen, Weihong Xu, Wenxing Li, Yanli Wang, Bin Liang, Jingfei Huang*, Wenzhong Xiao*, Qingpeng Kong*. System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity. Aging Cell. 2022,21(4): e13595. (IF=8.9, Q1)
11. Weilin Kong, Guoli Gu, Tong Dai, Beibei Chen, Yanli Wang, Zheng Zeng, Mintie Pu*. ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Commun. 2024, 15:9470. (IF=17.2, Q1)
