韩秀林，博士，硕士研究生导师
Email：xlhan@ynu.edu.cn
个人简介：
韩秀林，微生物学博士。实验室主要以模式生物大肠杆菌为研究对象，开展细菌耐药机制研究，为开发新型抗菌药物或提高现有药物的药效提供理论基础；改造微生物代谢途径，利用合成生物学生产重要天然活性产物；肠道菌群资源及其活性代谢产物的发掘和利用。另外实验室与植物所和花卉所合作，开展药用植物或特色花卉遗传转化及单倍体育种研究，创制或提升植物种质或花卉品质。
招生专业：
微生物学
生物与医药——微生物学方向
研究方向：
1、细菌耐药机制
2、生物合成与转化
3、微生物资源挖掘
代表性研究成果：
1. Yu-Peng Liang#; Ya-Lan Zhao#; Zhong-Wei Yin; Xiao-Wei Gong; Xiu-Lin Han*; Meng-Liang Wen*; Conserved Local Structural Motifs in Glycoside Hydrolase Families Facilitate the Discovery of Functional Enzymes, Journal of Agricultural and Food Chemistry, 2025, 77: 11983-11997.
2. Yupeng Liang#; Yalan Zhao#; Zhongwei Yin; Xin Zeng; Xiulin Han*; Mengliang Wen*; Functional and structural insights into α-L-Rhamnosidase: cloning, characterization, and decoding evolutionary constraints through structural motif, Archives of Microbiology, 2025, 207(3): 61.
3. Qiong Wang; Peng-Chao Zhan; Xiu-Lin Han*; Tao Lu*; Metagenomic and culture-dependent analysis of Rhinopithecius bieti gut microbiota and characterization of a novel genus of Sphingobacteriaceae, Scientific Reports, 2024, 14(1).
4. Yalan Zhao#; Yupeng Liang#; Gan Luo; Yi Li; Xiulin Han; Mengliang Wen*; Sequence-Structure Analysis Unlocking the Potential Functional Application of the Local 3D Motifs of Plant-Derived Diterpene Synthases, Biomolecules, 2024, 14(1): 120.
5. Cheng Ling; Feng Li; Jiang-Yuan Zhao; Meng-Liang Wen*; Xiu-Lin Han*; Research Progress of Nervonic Acid Biosynthesis, Journal of Oleo Science, 2023, 72(10): 889-900.
6. Xiaowei Gong#; Fan Li#; Yupeng Liang; Xiulin Han*; Mengliang Wen*; Characteristics of NtCCD1-3 from tobacco, and protein engineering of the CCD1 to enhance β-ionone production in yeast, Frontiers in Microbiology, 2022, 13(1): 1011297.
7. Fan Li#; Xiaowei Gong#; Yupeng Liang; Lijuan Peng; Xiulin Han*; Mengliang Wen*; Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum, Planta, 2022, 256(5).
8. Yuchen Wang; Xiaowei Gong; Fan Li; Shasha Zuo; Minggang Li; Jiangyuan Zhao; Xiulin Han*; Mengliang Wen*; Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae, Applied microbiology and biotechnology, 2021, 105(23): 8795-8804.
9. Han, Xiulin; Geng, Jian; Zhang, Lu; Lu, Tao*; The role of Escherichia coli YrbB in the lethal action of quinolones, Journal of Antimicrobial Chemotherapy, 2011, 66(2): 323-331.
10. Han, Xiulin; Dorsey-Oresto, Angella; Malik, Muhammad; Wang, Jian-Ying; Drlica, Karl; Zhao, Xilin; Lu, Tao*; Escherichia coli genes that reduce the lethal effects of stress, BMC Microbiology, 2010, 10(1): 35.
