个人简历

    

工作及教育经历

2019.10-至今   云南大学生命科学学院/中心，研究员，博导

2017.10-2019.7  休斯敦德克萨斯大学健康科学中心麦戈文医学院，博士后，导师：Cynthia Ju

2015.5-2017.9  科罗拉多大学药学系，安舒茨医学院，博士后，导师：Cynthia Ju

2009.9-2014.7 中科院上海巴斯德研究所, 博士，导师：李斌

2004.9-2009.6  吉林大学动物医学学院, 本科；

研究方向

药物性肝损伤很常见，几乎所有类别的药物都可引起肝脏疾病。然而，大多数药物诱导肝脏损伤的致病机理都尚未阐明。本课题组将致力于以药物诱导肝损伤小鼠为模型，研究不同分子，细胞及微生物群在急性或慢性肝脏疾病中的作用机理。

主要研究方向：

1. 各种肝脏细胞尤其是免疫细胞在药物诱导性肝损伤中的作用；

2. 肠道微生物群落在药物诱导性肝损伤中的作用

发表论文（共同第一作者* 共同通讯作者*）

1. Jia He, Bo Chen, Xiong Wang, Ruoxue Yang, Chengxiang Deng, Xiane Zhu, Keqin Wang, Lang Wang, Xiaokang Lu, Cheng Peng, Canpeng Li, Zhao Shan. Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD. eLife, (2025) (Under Review)

预印版本bioRxiv 2025.05.06.652369; doi: https://doi.org/10.1101/2025.05.06.652369

2. Yan Chen^#, Ruizhi Yang^#, Bin Qi*, and Zhao Shan*. Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer. eLife, (2024), https://elifesciences.org/articles/92994v1

3. Jia He; Chengxiang Deng; Leonard Krall; Zhao Shan; ScRNA-seq and ST-seq in liver research, Cell Regeneration, (2024), 12(1) https://doi.org/10.1186/s13619-022-00152-5

4. Yating Liu#, Guojing Tian#, Ziyi Wang, Junkang Zheng, Huimin Liu, Sucheng Zhu,

Zhao Shan*, Bin Qi* . Neuronal Detection Triggers Systemic Digestive Shutdown in Response to Adverse Food Sources. eLife (2025) 14:RP104028. https://doi.org/10.7554/eLife.104028.1

5. Yating Liu#, Qian Li#, Guojing Tian, Xinyi Zhou, Panpan Chen, Bo Chen, Zhao Shan*, Bin Qi* . Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via Intestinal UPRmt Activation. Nature Communications(2024). https://doi.org/10.1038/s41467-024-55013-3

6. Huimin Liu^#, Panpan Chen^#, Xubo Yang^#, FanRui Hao, Guojing Tian, Zhao Shan*, Bin Qi*. . Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense. Cell Reports (2024).

https://doi.org/10.1016/j.celrep.2024.115021

7. Shan, Zhao ; Li Leike; Atkins Constance Lynn; Wang Meng; Wen Yankai; Jeong Jongmin; Moreno Nicolas F; Feng Dechun; Gui Xun; Zhang Ningyan; Lee Chun Geun; Elias Jack Angel; Lee William; Gao Bin; Lam Fong Wilson; An Zhiqiang; Ju Cynthia; Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment, eLife, (2021), 439034

8. Zhao Shan ; Xiaodong Liu; Yuan Chen; Meng Wang; Yue Rachel Gao; Liangguo Xu; Wasim A. Dar; Chun Geun Lee; Jack Angel Elias; Pavel Davizon Castillo; Jorge Di Paola; Cynthia Ju ; Chitinase 3 -like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice, Hepatology, (2018), 67(6): 2384-2396

9. Shan, Zhao ; Ju Cynthia ; Hepatic Macrophages in Liver Injury., Frontiers in immunology, (2020), 11(322)

10. Shan Zhao ; Ju Cynthia ; Hepatic macrophages in drug-induced liver injury., Liver Research, (2019), 3(3-4): 170-175

11. Shan Z, Alvarez-Sola G, Uriarte I, Arechederra M, Fernandez-Barrena MG, Berasain C, Ju C, Avila MA.. Fibroblast growth factors 19 and 21 in acute liver damage. Annals of Translational Medicine (2018), 6(12):257

12. Shan J^#, Zhao B^#, Shan Z^#, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog (2017), 13: e1006773 (*co-first author)

13. Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem (2013), 288: 35093-103